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Safety of live attenuated influenza vaccine (LAIV) in children with ...
This is the first study to evaluate the safety and viral shedding of LAIV in Chinese healthy juveniles and adults. LAIV has many advantages. LAIV imitates natural infection, stimulating mucosal and humoral immunity without causing severe illness.
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In Year 2, VE was 51.9% (95% CI 42.0 to 60.1) for LAIV and 49.9% (95% CI 39.2 to 58.7) for IIV; relative efficacy of LAIV compared with IIV was 4.2% (95% CI −19.9 to 23.5). We found that LAIV and IIV were safe and moderately efficacious against laboratory-confirmed influenza virus infection.
Influenza Vaccine - Influenza Vaccine - Merck ... - The Merck Manuals
LAIV efficacy and its impact on vulnerable groups are still debated. This systematic review aims to investigate whether the LAIV is safe and effective in adults, including those with underlying clinical conditions, pregnant women, and children younger than 24 months.
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